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Cytoreductive
surgery and Hyperthermic Intraperitoneal Chemotherapy
(HIPEC) is an advanced and extensive surgical procedure combined
with a one-time treatment with heated chemotherapy at the end of the
operation. Only a very selected group of patients suffering from peritoneal
carcinomatosis (cancer spread within the abdominal surface) can undergo this
procedure. These typically include some patients with appendiceal cancer,
pseudomyxoma peritonei, ovarian cancer, mesothelioma, and colorectal cancer.
The procedure is performed in a few hospitals in the USA only. A
patient support website
is available.
HIPEC treatment is not
widely accepted by the US physician community despite a very good evidence
from a prospective randomized trial (Verwaal
2003), and other studies (Elias
2009,
Franko 2008,
Glehen 2004). This approach is considered a
gold standard in certain European countries, e.g. in France (Elias
2010). Nevertheless, given very poor prognosis of peritoneal
carcinomatosis, it is currently considered the best treatment option
available and is endorsed by a number of leading American surgical
oncologists (Esquivel
2007).
The first HIPEC
treatment in the Mercy Medical Center was in December 2008. At the time of
this writing the Mercy Medical Center is the only Iowa center offering this
therapy. Watch a news report and learn more on the
KCCI website.
Resources on HIPEC
from Mercy Surgical Oncologists
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Cytoreductive surgery
and hyperthermic intraperitoneal chemoperfusion versus systemic
chemotherapy alone for colorectal peritoneal carcinomatosis. (in press)
Franko J,
Ibrahim Z, Gusani NJ, Holtzman MP, Bartlett DL, Zeh HJ: Cancer 2010. In
press.
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Multivisceral resection does not affect morbidity
and survival after cytoreductive surgery and chemoperfusion for
carcinomatosis from colorectal cancer.
Franko J,
Gusani NJ, Holtzman MP, Ahrendt SA, Jones HL, Zeh HJ 3rd, Bartlett DL.
Ann Surg Oncol. 2008 Nov;15(11):3065-72. Epub 2008 Aug 19
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Aggressive surgical management of peritoneal
carcinomatosis with low mortality in a high-volume tertiary cancer
center. Gusani NJ, Cho SW, Colovos C, Seo S, Franko J,
Richard SD, Edwards RP, Brown CK, Holtzman MP, Zeh HJ, Bartlett DL. Ann
Surg Oncol. 2008 Mar;15(3):754-63
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Case-matched comparison of survival after
cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion
for peritoneal carcinomatosis versus liver resection for metastatic
colorectal cancer.
Franko J,
Gusani NJ, Holtzman MP, Ahrendt SA, Zeh HJ, Bartlett DL: 2008 ASCO
Annual Meeting. May 30 - June 3, 2008 in Chicago, Illinois. Abstract ID:
4058.
411 Laurel Street, Suite 2100
Des Moines, IA 50314-3017
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